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The Thai Journal of Pharmaceutical Sciences

Abstract

Background: Microencapsulation has received increasing attention across various industries, including pharmaceutics, cosmetics, foods, and biotechnology because of its many benefits. One method to prepare microparticles is an ionic gelation technique because of its simplicity and mild processing conditions. In this study, alginate beads encapsulating rice bran oil (RBO) for cosmetic applications were prepared using ionic gelation through vibration-nozzle coextrusion technology. Objective: The research aimed to investigate the effect of process parameters on the physical properties of alginate beads. Methods: Alginate beads encapsulating RBO were produced using Encapsulator B-390 with a concentric nozzle system. The shell material comprised 2% w/w sodium alginate, while 1.5% w/v calcium chloride served as the cross-linking agent. The study focused on the effects of various process parameters, including frequency, amplitude, electrode tension, and inner-outer flow rates on physical appearance, encapsulation of RBO in alginate beads, particle size, and size distribution. An experimental design was implemented to achieve alginate beads with optimal morphological characteristics. Results: The findings demonstrated that all investigated process parameters significantly influenced the physical properties of the alginate beads. The optimum process parameters were a frequency of 40 Hz, an amplitude of 6, an electrode tension of 0 V, an inner flow rate of 4 mL/min, and an outer flow rate of 14 mL/min. The resulting alginate beads exhibited an average size of 2.07 ± 0.27 mm, a spherical shape, and RBO encapsulation in the core, surrounded by a uniformly thick shell. Conclusion: These process parameters can be applied to develop alginate beads encapsulating cosmetic oils within a core-shell structure for application in cosmetic products.

DOI

10.56808/3027-7922.2971

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