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The Thai Journal of Pharmaceutical Sciences

Abstract

A common endocrine-gynecology problem affecting many women is polycystic ovary syndrome (PCOS). The precise etiology and pathophysiology of PCOS have not yet been fully understood, despite the discovery of some of the relevant mechanisms in its formation. We looked up the etiology, pathophysiology, diagnostic procedures, and therapy of PCOS in PubMed. All the causative elements of PCOS were carefully examined. This disease affects women from the time of conception until death, putting their health at risk and lowering their quality of life. In addition, it raises the morbidity and death rates. The earliest signs of PCOS appear throughout the puberty years. Acne, anovulation, and irregular menstruation are signs of both PCOS and normal female adolescence. The same sickness might have several distinct phenotypes, so it is important to look at each one separately since they could respond differently to different therapies and have different consequences. Depending on their symptoms, female PCOS patients are treated differently. Menstrual issues, symptoms associated with androgens, or infertility due to ovulatory disruption are a few examples of these. In many situations, changing one’s lifestyle and using complementary and alternative treatments is considered the first line of treatment. Antiandrogens, insulin sensitizers, hormonal tablets, and several supplements have data supporting their use in PCOS as pharmacological treatments. Because there are few completed clinical trials with a small population and mainly without outcomes on PCOS repurposed drugs, more studies and well-designed clinical trials would be beneficial. Furthermore, learning more about PCOS might aid in the development of new drugs, assuming the effect of newly identified mechanisms.

DOI

10.56808/3027-7922.2909

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