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The Thai Journal of Pharmaceutical Sciences

Abstract

Quercetin (QE) is a flavonoid found in several fruits and vegetables such as shallot, onion, and apple with proven antioxidant and anti-inflammatory properties that protect against and treat airway inflammation induced by particulate matter. Nanostructured lipid carriers (NLCs) with various liquid lipid types were employed to deliver QE into the respiratory tract. Physical properties of NLC formulations including particle size, stability, and entrapment efficiency were compared. Particle size of B_VCO and B_OLO formulations was 308.0 ± 0.4 nm and 104.8 ± 1.5 nm, respectively. After the temperature cycling test, particle size of B_OLO increased, while B_VCO was not significantly different. Entrapment efficiency of NLC formulations was around 50%. After QE incorporation, QE_VCO (318.3±7.4 nm) had smaller particle size than OLO (364.6 ± 0.4 nm) and was more stable with no significant difference in particle size. Percentage viability in human fetal lung fibroblast cells (MRC-5) of NLC formulations was higher than 80% and comparable with 10% w/w of CRH40 solution, suggesting no toxicity. QE_VCO effectively prevented particulate matter-induced DNA damage by a reduction of 0.68 ± 0.17 times compared to the control group and showed potential for use as an alternative treatment for DNA damage protection triggered by particulate matter.

DOI

10.56808/3027-7922.2905

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