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The Thai Journal of Pharmaceutical Sciences

Abstract

The global skin-lightening product market is expanding every year resulting in a high demand for skin-lightening herbal extracts that are effective and safe. Moreover, herbal plants are very popular in Thailand and can bring Thai farmers satisfactory income. This research hence aimed to discover new plant extracts with potential skin-lightening properties. Extractions of different parts of five plants originally cultivated in Southern Thailand including Artocarpus integer Spreng. (AI), Artocarpus heterophyllus Lam., Garcinia atroviridis Griff. Ex T. Anderson, Glycyrrhiza glabra Linn., and Anacardium occidentale L. were performed and determined for their anti-tyrosinase, anti-melanogenesis, anti-oxidant activity, and cell toxicity. It was found that a new extract from AI fruit peel had superior potential and could be used as an active ingredient in skin-lightening products when compared to other extracts due to its great anti-tyrosinase, anti-melanogenesis, anti-oxidant activities, and safety.

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