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The Thai Journal of Pharmaceutical Sciences

Abstract

Purpose of the research: The study of medicinal plants has made it possible to develop products and drugs for the treatment of different diseases. Several plants in India have a history of popular use for the treatment of CNS disorders. The objective of this work was to provide information on the phytochemical profile and central nervous system (CNS) activity of the ethanolic extract of Borago officinalis flowers (Ee). Results: The preliminary phytochemical and HPLC evaluation of Ee established the presence of alkaloids, flavonoids, phenols, tannins, terpenes and steroids. The acute toxicity study revealed that administration of 2000 mg/kg body weight of Ee showed CNS depressant effect and there was no mortality observed up to 14 d. Thus, 100 and 200 mg/kg of Ee was selected for the spontaneous motor activity, muscle relaxant activity, effect on pentobarbital sodium-induced sleeping time and central analgesic activity. The results revealed that Ee at 100 and 200 mg/kg showed a significant (P < 0.001) reduction in spontaneous motor function, muscle relaxant activity and central analgesic activity. Whereas both low and high doses showed a significant (P < 0.001) increase in pentobarbital sodium-induced sleeping time. Conclusion: The result suggests that Ee has a CNS depressant and analgesic activity in tested rodent models.

DOI

10.56808/3027-7922.2828

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