The Thai Journal of Pharmaceutical Sciences
Abstract
In modern pharmaceutical drug delivery design, controlled drug release has become more appealing research work for obtaining a better drug delivery system with reliability, efficiency, and safe drug release. In controlled drug delivery applications, different polymers are extremely useful. In the current study, poly(acrylic acid) hydrogels were made using a redox polymerization process using methylenebisacrylamide as the crosslinker with potassium persulfate and sodium metabisulfite as free-radical initiators. Various analytical methods, such as thermogravimetric analysis, scanning electron microscope, and Fourier transform infrared, were used to identify the prepared hydrogels. The water intake behavior of the synthesized hydrogels was investigated under various experimental conditions of various pH solutions, chemical composition, and swelling bath temperature. The controlled drug release behavior of a doxycycline-loaded hydrogel was investigated under in vitro conditions, and the impact of various factors such as temperature, the chemical composition of the hydrogel, and the pH of the release media on the drug release study was investigated. According to the drug release results, drug release was found to be 39% at acidic pH 1.2 and 99% at alkaline pH 7.4 after 10 h, following the Higuchi model.
DOI
10.56808/3027-7922.2820
Recommended Citation
Madhusudana Reddy, Tukiakula; Mamatha, Ganjeenahalli Puttagiddappa; Mahadevaiah, Thippaiah Demappa; Shivakumara, Lachakkal Rudrappa; and Satyanarayan, Nayak Devappa
(2023)
"Synthesis and characterization
of poly(acrylic acid) hydrogel for
doxycycline drug release study,"
The Thai Journal of Pharmaceutical Sciences: Vol. 47:
Iss.
2, Article 8.
DOI: https://doi.org/10.56808/3027-7922.2820
Available at:
https://digital.car.chula.ac.th/tjps/vol47/iss2/8