Delamanid and bedaquiline – A review on analytical methods determined with recent updates on pharmacokinetics, pharmacodynamics, and drug-drug interaction

Authors

Kamini Sethy
Konduri Raja Rajeswari
Gopal Krishna Padhy

Abstract

Delamanid and bedaquiline are recently approved drugs for the treatment of multi-drug resistance tuberculosis (TB). It was found that the concomitant use of both drugs helped in treating patients with high drug-resistant strains. Fixed dose combination of delamanid and bedaquiline can be a possibility to control drug resistance TB. Therefore, the objective of this review was to collect data on different analytical methods used so far for the specific quantitation of delamanid and bedaquiline. Such information would be valuable to the research community to develop a new analytical method for the simultaneous analysis of these drugs. Analytical techniques are existing for individually for the quantification of delamanid and bedaquiline, but an operative and dependable analytical technique has not been reported for their combination. Majority of the analysis is carried out using chromatographic methods, namely, RP-HPLC, UPLC, and LCMS/MS. However, the literature revealed lack of colorimetric, spectrofluorometric, spectrophotometric, and electrophoretic method for estimation of both the drugs either individually or simultaneously. Hence, there is a huge scope for the development of wide varieties of analytical methods for delamanid and bedaquiline in different sample matrix.

DOI

10.56808/3027-7922.2813

Recommended Citation

Sethy, Kamini; Raja Rajeswari, Konduri; and Padhy, Gopal Krishna (2023) "Delamanid and bedaquiline – A review on analytical methods determined with recent updates on pharmacokinetics, pharmacodynamics, and drug-drug interaction," The Thai Journal of Pharmaceutical Sciences: Vol. 47: Iss. 2, Article 1.
DOI: https://doi.org/10.56808/3027-7922.2813
Available at: https://digital.car.chula.ac.th/tjps/vol47/iss2/1