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The Thai Journal of Pharmaceutical Sciences

Abstract

Pereskia bleo is proposed for a functional food due to its health benefits. Its bioactive compounds and bioactivities need to be understood. This study aimed to identify the bioactive compounds and bioactivities of the ethanol extracts from the leaves, fruits, and needles of P.bleo. The extracts were analysed for their phenolic and flavonoid contents and the phytochemical profiles were developed by an LC- MS/MS-QTOF. The extracts were investigated for their antioxidant (DPPH scavenging, Fe(II) chelating, and total antioxidant) activities. Inhibitory activities against enzymes involved in pathologies were investigated in vitro, including α-glucosidase, lipase, and xanthine oxidase. The leaves exhibited the highest content of phenolic and flavonoid, followed by the fruits and the needles. The LC- MS/MS-QTOF analysis identified puerarin-4′-O-glucoside in the leaf, fruit and needle extracts. Isorhamnetin-3-O-β- gentiobioside, 7-O-α-L-rhamnosyl-3-O-β-D-glucopyranosyl-kaempferol, yuankanin were identified specifically in the leaf extract. The fruit extract contained 5,7-dihydroxychromone-7-β-D-glucoside and 5-hydroxy-7,8-dimethoxyflavone, whereas the needle extract was characterized by N-cis-feruloyl-typamine. All extracts showed moderate or weak antioxidant and enzymes (α-glucosidase, lipase, trypsin, and xanthine oxidase) inhibitory activities. Several bioactive compounds were detected for the first time in the ethanol extracts of P.bleo. The data suggest P.bleo can be further explored as natural agents with pharmacological properties.

DOI

10.56808/3027-7922.2793

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