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The Thai Journal of Pharmaceutical Sciences

Abstract

Diabetes is a significant public health issue that has gradually grown worldwide. The disorder induces substantial morbidity, death, and long term complications and is a major contributing factor for cardiovascular disease. Hence there is a need to develop successful natural antidiabetic agents that can be used on a long-term basis without any side effects. Column chromatography was used to separate the phytoconstituents of the unripe fruit extract of Spondias mombin. They were characterized by IR, 1H NMR, 13C NMR and mass spectra. The in vitro antidiabetic activity was evaluated using α-amylase inhibition assay and α-glucosidase inhibition assay. The phytochemical screening of the fruits of Spondias mombin yielded a flavanoid Apigenin and a triterpenoid β-Amyrin from the ethanol extract. The percentage inhibitory action against α-amylase enzyme and α-glucosidase enzyme was dose dependently increased in a concentration range from 6.25 µg/ml to 50 µg/ml. But there was a decrease in the percentage inhibition at higher concentrations. Acarbose was taken as standard. The phytochemical investigation of fruit extract of Spondias mombin led to isolation of two phytochemical constituents namely Apigenin and β-Amyrin. The results suggest that the aqueous and ethanol extracts marginally inhibit α-amylase and α-glucosidase enzymes.

DOI

10.56808/3027-7922.2792

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