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The Thai Journal of Pharmaceutical Sciences

Abstract

The present study aimed at determining the neuroprotective role of palmatine isolated from Tinospora cordifolia (TC) leaves on neurobehavioral parameters in aluminium chloride induced oxidative stress and to assess the biochemical and histopathological alterations brought about by the same on mouse brain. Isolated Palmatine showed antioxidant potential confirmed with DPPH assay. The purity of the isolated palmatine was confirmed with FTIR, C-13 NMR and mass spectroscopy. Four groups of animals with doses of 10 and 20mg/kg respectively were studied against aluminium chloride induced oxidative stress (100mg/kg) for the alterations it brought in neurobehavioral parameters using actophotometer, rotarod test, Morris water maze, elevated plus maze and Eddy’s hot plate method. Aluminium chloride adversely affected the performance of animals in all the above tests confirming its ability to induce anxiety, depressions, motor incoordination, lack of memory and learning and nociception. Palmatine at both doses effectively improved learning, motor coordination, balance and memory, ameliorated anxiety and locomotion in animals. Palmatine also improved the antioxidant status by improving SOD and catalase in mouse brain and lowered lipid peroxidation. Histopathological data confirmed the protective role of palmatine and finally concluded the protective influence of isolated palmatine on neurobehavioral parameters in aluminium chloride induced oxidative stress.

DOI

10.56808/3027-7922.2788

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