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The Thai Journal of Pharmaceutical Sciences

Abstract

The α-glucosidase inhibitory and antioxidant activities of Bauhinia strychnifolia Craib in vitro have been explored; however, its effectiveness in vivo is still unknown. This study examined the hypoglycemic effects of B. strychnifolia extract. Acute toxicity was also investigated in mice using the up-and-down method. The experiments were carried out in both sexes of Wistar rats and female ICR mice. The results showed that the oral LD50 of the plant extract was greater than 5000 mg/kg. For the anti-diabetic investigation, diabetes was induced in rats by subcutaneous injection of alloxan (125 mg/kg). The hypoglycemic effect was evaluated by oral administration of the extracts (300, 500, and 750 mg/kg) to the diabetic rats once daily for 14 days. The results revealed that 500 and 750 mg/kg of the plant extract lowered blood glucose levels by 35.63% and 33.04%, respectively, on day 14. In addition, a 2-h oral glucose tolerance test was performed in normal rats, in which the extract (500 mg/kg, p.o.) did not control plasma glucose after glucose loading. In conclusion, the plant extract has low toxicity and the potential to act as an anti-diabetic drug. Its hypoglycemic effect may be the result of other effects unrelated to insulin secretagogue. However, the anti-diabetic effect might be due to the antioxidant and α-glucosidase inhibitory activities of the flavonoids constituents.

DOI

10.56808/3027-7922.2786

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