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The Thai Journal of Pharmaceutical Sciences

Abstract

Quercetin has been known to have anti-inflammatory effects. Information regarding the anti-inflammatory effects of quercetin or its derivatives on inflammatory mediators and miRNAs is abundant and varied. However, a comprehensive understanding of its pharmacological actions at the cellular and molecular levels needs to be studied. Therefore, quercetin and its derivatives were studied in this systematic review to investigate how they affect the expressions of miRNAs and inflammatory mediators and their respective roles in the mechanisms of anti-inflammatory actions. A literature search in PubMed and Scopus databases was carried out based on the PRISMA protocol. Out of 2964 articles identified, 47 eligible articles were reviewed. Quercetin, isorhamnetin, rutin, hyperoside, quercitrin, and quercetin pivaloyl ester had anti-inflammatory activity by down-regulating the expressions of TNF-α, IL-1, IL-2, IL-6, IL-8, IL-12, COX-2, or PGE2. Quercetin-3-glucuronide and quercetin-3-O-β-glucuronide did not affect the expressions of inflammatory mediators. Quercetin, isorhamnetin, and tamarixetin had anti-inflammatory activities through miRNAs modulation pathways, causing down-regulation of pro-inflammatory cytokines or up-regulation of anti-inflammatory cytokines. It remained unclear how quercetin and its derivatives affect IL-10, miR-146a, and miR-155. In conclusion, quercetin and its derivatives have anti-inflammatory effects by regulating miRNAs and inflammatory mediators. MiRNAs regulate inflammatory mediators in either a positive or negative manner.

DOI

10.56808/3027-7922.2785

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