The Thai Journal of Pharmaceutical Sciences


Vegetable oils serve as affordable, non-toxic, and eco-friendly solvents for plant extraction. Chemical fingerprinting shows that vegetable oil-based cannabis has a cannabinoid profile similar to that of organic solvent-based cannabis. All samples possess antioxidative effects as they contain several cannabinoids and other unidentified compounds, with rice bran oil-based sample exhibiting the strongest effect. Tetrahydrocannabinol (THC) and cannabidiol (CBD) content in sesame oil-based and perilla seed oil-based cannabis differed significantly from that in virgin coconut oil (VCO)-based cannabis. In addition, THC and CBD content in all vegetable oil-based samples prepared using the heating and frying method differed significantly from that in samples prepared using conventional methods. The VCO-based cannabis was chosen to preliminarily test its photoprotective effect and antioxidant enzyme activity. The results showed that it can protect UVA-irradiated HaCaT cells. Pretreatment with VCO-based cannabis can promote Nrf-2/HO-1 signaling, thereby upregulating antioxidant enzymes and increasing the capacity of keratinocytes to detoxify oxidative insults. Herein, we present the first overview of the cannabinoid profile of vegetable oil-based cannabis, which can be used for quality control during the development of vegetable oil-based cannabis products. Furthermore, the skin photoprotective properties of oil-based extracts can provide supporting evidence for the formulation of cannabis-based skincare products.



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