Antidiabetic study and teratogenicity evaluation of ethanolic extract of Chromolaena odorata Linn.

Authors

Indah Solihah
Yuni Fitriani
Meutia Reni Noprida
Herlina
Riana Sari Puspita Rasyid
Tri Suciati

Abstract

There is considerable interest in herbal medicine in developing antidiabetic alternative therapy based on plant-derived compounds that would reduce oral hypoglycemic agent-related adverse effects while staying safe during pregnancy. The purpose of this in vivo study was to evaluate the ethanolic extract of Chromolaena odorata L. leaves (ECOL) in alloxan-induced diabetes and its teratogenic effect. The hypoglycemic impact of ECOL increased when the extract dose was raised. Three doses of ECOL (125, 250, and 500 mg/kg body weight) showed a 27.29%, 34.68%, and 52.24% hypoglycemic effect, respectively. While, the standard insulin (1 IU/kg BW) group shown a 31.38% hypoglycemic effect (P < 0.05). The ECOL groups improved beta-cells in the islets of Langerhans in histological examinations of the pancreas. The ECOL groups showed no influence on fetal mortality, however, had a substantial impact on the fetal ossification process (P < 0.05) in the teratogenic study.

DOI

10.56808/3027-7922.2640

First Page

561

Last Page

569

Recommended Citation

Solihah, Indah; Fitriani, Yuni; Noprida, Meutia Reni; Herlina; Rasyid, Riana Sari Puspita; and Suciati, Tri (2022) "Antidiabetic study and teratogenicity evaluation of ethanolic extract of Chromolaena odorata Linn.," The Thai Journal of Pharmaceutical Sciences: Vol. 46: Iss. 5, Article 9.
DOI: https://doi.org/10.56808/3027-7922.2640
Available at: https://digital.car.chula.ac.th/tjps/vol46/iss5/9