•  
  •  
 

The Thai Journal of Pharmaceutical Sciences

Abstract

Aim: The current investigation work sums up the enumerating improvement and depiction of brinzolamide and brimonidine tartrate ophthalmic nanoemulsion giving widened helpful effect and improved visual penetration for treating glaucoma. Methodology: Nanoemulsion was formulated using polysorbate 80, castor oil and glycerol using the continuous emulsification technique. Preliminary batches were screened subject to in vitro medication release, globule size, zeta potential, and stability with regards to accelerated and long time. Nanoemulsions were evaluated for ex vivo optical irritancy using the hen’s egg chorioallantois membrane test model. Results: Screened nanoemulsion batches showed a low mean globule width (<220 nm), higher penetrability (>75%) in comparison with one of the marketed suspensions for least 3 months at 25°C/40% RH and 40°C/25% RH. Screened nanoemulsion batches exhibited non-irritant in comparison like the available batches. Conclusion: Therefore, these nanoemulsion formulations containing brinzolamide and brimonidine tartrate would fill in as a further developed prescription movement system giving greater healing effect and better patient compliance for the treatment of glaucoma.

DOI

10.56808/3027-7922.2623

First Page

413

Last Page

424

Download

Included in

Pharmacology Commons

Share

COinS