The Thai Journal of Pharmaceutical Sciences
Abstract
Curcumin-loaded liposomes comprising dipalmitoylphosphatidylcholine, cholesterol, and dioleoylphosphatidylethanolamine (72:8:20 mole ratio) were prepared by the thin-film hydration method, followed by probe sonication to achieve a mean diameter (FSI) pre-cooled at 2–8°C for at least 90 min at 15 L/min. Curcumin recovered from the impactor and nebulizer was quantified using a validated high-performance liquid chromatography method. Overall, 2.5% w/w curcumin-loaded liposomes was the optimal formulation based on the maximum encapsulation efficiency of approximately 87% and mean hydrodynamic diameter of 97 nm. This chosen curcumin concentration was effectively aerosolized with a fine particle fraction of 53.25%, and a fine particle dose of 53 μg being deposited on the lower stage of the FSI (cutoff diameter 5 μm).
Publisher
Faculty of Pharmaceutical Sciences, Chulalongkorn University
First Page
293
Last Page
299
Recommended Citation
Mohari, Safura Binti Mohd; Taylor, Kevin M. G.; and Nimmano, Nattika
(2022)
"Preparation and characterization of curcumin-loaded liposomes for delivery to the lungs,"
The Thai Journal of Pharmaceutical Sciences: Vol. 46:
Iss.
3, Article 7.
Available at:
https://digital.car.chula.ac.th/tjps/vol46/iss3/7