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The Thai Journal of Pharmaceutical Sciences

Abstract

Black cumin seed oil (BSCO) is widely used to maintain health and strengthen the people of Indonesia’s immune system and proved to be safe for kidneys. However, the effect of BSCO usage in a healthy kidney is remaining unknown. This study was aimed to determine the impact of the 20-day administration of BCSO on kidney function in healthy volunteers. We conducted a pre- and post-control design trial in 36 healthy volunteers. The volunteers had to hold a valid health certificate from the hospital, be willing to be involved in the research as evidenced by their willingness to complete and sign an informed consent, and be aged between 18 and 50 years. Pregnant women and participants allergic to BCSO were excluded from the study. BCSO was given for 20 days in three dose regimes: 3 × 1, 3 × 2, and 3 × 3 capsules/day. Blood pressure, pulse, weight, and blood chemistry of kidney function was observed, and hemograms and urinalyses were performed before and after treatment. One-way ANOVA and a repeated measures analysis were used to examine the mean difference of clinical parameters outcomes. BCSO administration with the three-dose levels for 20 days did not change blood pressure, hemogram, blood urea levels, blood creatinine levels, or specific gravity and urine pH (P > 0.05). Based on the result, it can be concluded that the administration of BCSO for 20 days in healthy volunteers has not been able to show its effect on kidney function. It is necessary to plan a study with a longer duration and a higher dose to determine the effect of BCSO on the kidney function.

DOI

10.56808/3027-7922.2570

First Page

272

Last Page

278

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