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The Thai Journal of Pharmaceutical Sciences

Abstract

Indole, a versatile outstanding heterocyclic compound, engaged in numerous pharmacological properties due to their multiple biochemical processes. The remarkable indole moiety resembles with numerous protein structures. The fascinating molecular framework of indole makes its suitable for drug development. Indole derivatives mimic the peptides structure and bind reversibly to several enzymes, which contribute enormous opportunities to develop novel drugs with distinct mechanism of action. The presence of nitrogen-based heterocycles in several compounds has been investigated enormously as the core structures comprise several biologically appropriate molecules found active in different diseases. The investigations conducted worldwide have shown outstanding impact for scientists, working on indole derivatives to formulate commercially approved indole derivatives. Numerous drug molecules having indole moiety are under investigation to control disease. The explicit characteristics with the rationale and foundation of the research topic are to establish and assist the formulator. In this review, we summarized various studies reported on anticancer, antifungal, antiplatelet, antidiabetics, antimalarial, antimicrobial, antidiabetic, antiviral, antifungal, anticonvulsant, antifertility, anti-inflammatory, antidepressant, antioxidant, antiestrogenic, and antitubercular of past several decades. This review article would provide a platform for researchers in tactical outline of novel indole derivatives having numerous encouraging biological activities with decreased toxicity and side effects.

Publisher

Faculty of Pharmaceutical Sciences, Chulalongkorn University

First Page

233

Last Page

250

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