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The Thai Journal of Pharmaceutical Sciences

Abstract

Objective: The objective of the present study is to evaluate the antiulcer property of ethanolic extract of Phyllanthus reticulatus Poir. against pylorus ligation-, ethanol-induced, and stress-induced ulcer models in Wistar albino rats. Materials and Methods: Three models – pylorus ligation-induced ulcer, ethanol-induced ulcer, and swim stress-induced ulcer – were used to induce ulcer in Wistar rats. The animals were treated with 200 mg/kg and 400 mg/kg p. o of the ethanolic extract of P. reticulatus Poir, to estimate the gastroprotective potential. The effect of P. reticulatus Poir. on pH of the gastric juice, volume of acid secretion, total and free acidity, ulcer index, and % ulcer protection was assessed to determine the gastroprotective potential. Results: A decrease in ulcer index was observed in all three models after treatment with P. reticulatus Poir. In pylorus ligation model, the doses of 200 mg/kg and 400 mg/kg exhibited % protection of 88.11 and 91.53, respectively. In ethanol-induced ulcer model, 200 mg/kg and 400 mg/kg displayed % protection of 50.40 and 60.94, respectively. In stress-induced ulcer model, 200 mg/kg and 400 mg/kg displayed % protection of 60.94 and 72.31, respectively. A decrease in aggressive factors and an increase in protective factors were observed during the estimation of biochemical parameters. Conclusion: The present study proves that the ethanolic extract of P. reticulatus Poir. possesses significant gastroprotective property.

Publisher

Faculty of Pharmaceutical Sciences, Chulalongkorn University

First Page

161

Last Page

166

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