Anti-inflammatory activity of new 1,3,4-oxadiazole derivatives

Authors

Banylla Felicity Dkhar Gatphoh
Natasha Naval Aggarwal
Hemanth Kumar
B. C. Revanasiddappa

Abstract

A new series of 1,3,4-oxadiazole derivatives (3a-j) were synthesized by reacting p-toluic benzhydrazide (1) and substituted aromatic aldehydes (2) in the presence of ceric ammonium nitrate as catalyst and dichloromethane as a solvent medium. The structures of the new compounds were assigned based on IR, 1H-NMR, and mass spectral data and further evaluated for their in vitro anti-inflammatory potential using various protein denaturation methods following bovine serum and egg albumin assay. Some tested compounds 3e, 3f, and 3i displayed moderate anti-inflammatory activity compared to the standard diclofenac sodium.

Publisher

Faculty of Pharmaceutical Sciences, Chulalongkorn University

First Page

492

Last Page

497

Recommended Citation

Gatphoh, Banylla Felicity Dkhar; Aggarwal, Natasha Naval; Kumar, Hemanth; and Revanasiddappa, B. C. (2021) "Anti-inflammatory activity of new 1,3,4-oxadiazole derivatives," The Thai Journal of Pharmaceutical Sciences: Vol. 45: Iss. 6, Article 8.
Available at: https://digital.car.chula.ac.th/tjps/vol45/iss6/8