The Thai Journal of Pharmaceutical Sciences
Abstract
Introduction: Chitosan, a biopolymer with 97% degree of deacetylation, was used herein, to synthesize an amino sugar anionic surfactant of varied alkyl chain length, using a microwave-assisted synthesis. We were also examined their properties in aqueous form. Objectives: The objectives of the study were to increase the surface activity and water solubility of chitosan derivatives. Materials and Methods: Structural features and crystallinity were confirmed using Fourier transform infrared, ¹H-nuclear magnetic resonance, and X-ray diffraction. The chitosan by itself was found to have weak surface-active properties since it has no hydrophobic segment. Results: The microwave-assisted synthesized sugar amino-based anionic surfactant, synthesis of (2-hydroxyl-3-butoxyl) propyl-succinyl-chitosan-succinyl chitosan was found to have excellent surface-active and detergency properties. The aggregation behavior of amino sugar anionic surfactant was characterized by surface tension, which indicated that it had good surface activity. Conclusion: We believe that good surface activities of synthesized water-soluble surfactants can be used in the formulations of face wash, body wash, liquid detergents, more applications in pharmaceutical, medicine and food industry, etc.
Publisher
Faculty of Pharmaceutical Sciences, Chulalongkorn University
First Page
461
Last Page
469
Recommended Citation
Singh, P. S.; Mali, Suraj N.; Sangale, N. R.; and Pratap, Amit P.
(2021)
"Synthesis of (2-hydroxyl-3-butoxyl) propyl-succinyl-chitosan – An amino sugar anionic surfactant under microwave irradiation and its application,"
The Thai Journal of Pharmaceutical Sciences: Vol. 45:
Iss.
6, Article 4.
Available at:
https://digital.car.chula.ac.th/tjps/vol45/iss6/4