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The Thai Journal of Pharmaceutical Sciences

Abstract

Objectives: This study compared the hepatoprotective activity of Pterocarpus santalinoides cold maceration extract (PSCME) with P. santalinoides Soxhlet extract (PSSE). Materials and Methods: Phytochemical constituents of both extracts were determined. 45 albino rats, randomly assigned into 9 groups (1–9) of 5 rats each, were used for the study. Liver damage was induced in groups 1–8 using carbon tetrachloride (CCl4). Group 1 served as untreated control, Groups 2–7 were treated with 50, 250 or 500 mg/kg PSCME or PSSE, Group 8 was treated with 100 mg/kg silymarin, while Group 9 served as normal control. Treatment was done orally for 15 days. Serum enzyme activities, proteins, cholesterol and bilirubin levels, relative liver weight and liver histomorphology were evaluated. Results: There were higher concentrations of phenols and saponins in PSCME than in PSSE. 250 mg/kg dose of both PSCME and PSSE significantly (P < 0.05) protected hepatocellular integrity, enhanced hepatic bilirubin clearance, ameliorated hepatomegaly, and also led to less severe vacoulation and necrosis of hepatocytes in the rats given CCl4. Conclusion: Extracts of P. santalinoides obtained by cold maceration and Soxhlet extraction techniques are of nearly equal hepatoprotective potency. The heat applied during Soxhlet extraction had no adverse effect.

DOI

10.56808/3027-7922.2525

First Page

442

Last Page

450

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