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The Thai Journal of Pharmaceutical Sciences

Abstract

To develop potent anticancer compounds using benzothiazole scaffolds group-based quantitative structure and activity relationship (GQSAR) analysis was performed on 41 reported benzothiazole derivatives for identification of structural fragments. Benzothiazole dataset was fragmented into two fragments (R1 and R2). GQSAR models were generated using multiple linear regression. GQSAR analysis revealed the presence of hydrophobic groups on R1 will potentiate anticancer activity. The generated models are giving insight into the benzothiazole structural requirements which will be optimized for design of anticancer drugs.

DOI

10.56808/3027-7922.2523

First Page

428

Last Page

432

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