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The Thai Journal of Pharmaceutical Sciences

Abstract

Background: Peptic ulcer disease is one among the major cause of hospitalization in the gastroenterology department. Objective: The study was conducted to evaluate the gastroprotective and anti-ulcerogenic activity of Averrhoa carambola L. aqueous extract and its ghritha formulation on rat models. Materials and Methods: The antiulcer activity of A. carambola L. fruit extract was assessed by inducing ulcer using indomethacin and using pylorus ligation-induced ulcer models. The drug activity was compared to standard drugs omeprazole 30 mg/kg and sucralfate at a dose of 100 mg/kg. The parameters such as gastric pH, gastric acid volume, total acidity, free acidity, and ulcer index was assessed. Results: The aqueous fruit extract of A. carambola L. showed potent ulcer protective activity up to 71.36% and 76.48% in indomethacin and pylorus ligation, respectively. Similarly, ghritha formulation also showed the ulcer protective activity up to 74.78% and 80.22% in both models at a dose of 1160 mg/kg. There was a reduction in the gastric volume, total acidity, free acidity, and ulcer index and a rise in the gastric pH of test animals. Conclusion: A significant gastroprotective and anti-ulcerogenic activity are shown by the fruit extract of A. carambola L. both of the ulcer model.

Publisher

Faculty of Pharmaceutical Sciences, Chulalongkorn University

First Page

253

Last Page

258

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