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The Thai Journal of Pharmaceutical Sciences

Abstract

Introduction: Moa Chub’s gout formulation (MCHGF), a traditional Thai herbal remedy, is used for the treatment of pain and swelling related to gout. Objective: This study aimed to determine MCHGF’s analgesic, anti-inflammatory, and antihyperuricemic effects. Materials and Methods: The analgesic activity of MCHGF was studied in mice using an acetic acid-induced writhing test and the hot-plate method. The anti-inflammatory activity of MCHGF was evaluated in rats using carrageenan-induced paw edema. The antihyperuricemic activity of MCHGF was tested in vivo using the model of potassium oxonate-induced hyperuricemia mice. MCHGF doses of 50, 100, and 200 mg/kg/day were used in this study. The in vitro xanthine oxidase (XO) inhibitory activity was carried out to investigate the mechanism of uric acid- lowering effect. Results: The results showed that MCHGF extract reduced writhing response in the acetic acid test, while MCHGF doses of 100 and 200 mg/kg/day increased the reaction time in the hot-plate method. In addition, MCHGF significantly inhibited carrageenan-induced paw edema at 3 and 4 h after carrageenan injection. Moreover, all doses of MCHGF significantly reduced the serum uric acid levels. However, MCH GF did not inhibit XO activity in in vitro study. Conclusion: MCHGF demonstrated analgesic, anti-inflammatory, and antihyperuricemic activities in the experimental animal models.

Publisher

Faculty of Pharmaceutical Sciences, Chulalongkorn University

First Page

235

Last Page

241

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