The Thai Journal of Pharmaceutical Sciences
Article Title
Abstract
Objectives: Hypertension and type 2 diabetes are common comorbidities. Studies have shown that hypertension is twofold as common in diabetic patients compared with non-diabetics. Excessive intake of dietary salt has reportedly caused increase in blood pressure. This study investigated the effects of high dietary salt intake on diabetic rats. Materials and Methods: Twenty-eight animals were randomly selected into four groups (n = 7). Group 1 (normal control), fed with standard rats’ feed; Group 2 (diabetic control), streptozotocin-induced diabetic rats fed with normal diet; Group 3 (salt control), fed with 8% salt (high salt) diet; Group 4 (test group), streptozotocin-induced diabetic rats fed with high salt diet. Fasting blood glucose was monitored every 7 days. After 28 days of the study, blood pressure measurement was taken using tail cuff non-invasive method (CODA). Histology of the pancreas and kidney was done using hematoxylin and eosin staining. P < 0.05 was considered statistically significant. Results and Conclusion: Glucose levels of the test group reduced significantly when compared with the diabetic control group. This study suggests that high dietary salt intake plays a role, not only in reducing fasting blood glucose in a manner that is not yet understood but also causes distortion in the histomorphology of the pancreas and renal tissues.
Publisher
Faculty of Pharmaceutical Sciences, Chulalongkorn University
First Page
172
Last Page
177
Recommended Citation
Asiwe, Jerome Ndudi; Anachuna, Kenneth Kelechi; Moke, Emuesiri Goodies; Sanusi, Kamaldeen Olalekan; Okonofua, David Ehikhuemen; Omeru, Oghenerukevwe; and Fasanmade, Adesoji Adedipe
(2021)
"High dietary salt intake alleviates fasting blood glucose in streptozotocin-induced diabetic male Wistar rats,"
The Thai Journal of Pharmaceutical Sciences: Vol. 45:
Iss.
3, Article 2.
Available at:
https://digital.car.chula.ac.th/tjps/vol45/iss3/2