Objectives: Hypertension and type 2 diabetes are common comorbidities. Studies have shown that hypertension is twofold as common in diabetic patients compared with non-diabetics. Excessive intake of dietary salt has reportedly caused increase in blood pressure. This study investigated the effects of high dietary salt intake on diabetic rats. Materials and Methods: Twenty-eight animals were randomly selected into four groups (n = 7). Group 1 (normal control), fed with standard rats’ feed; Group 2 (diabetic control), streptozotocin-induced diabetic rats fed with normal diet; Group 3 (salt control), fed with 8% salt (high salt) diet; Group 4 (test group), streptozotocin-induced diabetic rats fed with high salt diet. Fasting blood glucose was monitored every 7 days. After 28 days of the study, blood pressure measurement was taken using tail cuff non-invasive method (CODA). Histology of the pancreas and kidney was done using hematoxylin and eosin staining. P < 0.05 was considered statistically significant. Results and Conclusion: Glucose levels of the test group reduced significantly when compared with the diabetic control group. This study suggests that high dietary salt intake plays a role, not only in reducing fasting blood glucose in a manner that is not yet understood but also causes distortion in the histomorphology of the pancreas and renal tissues.
Faculty of Pharmaceutical Sciences, Chulalongkorn University
Asiwe, Jerome Ndudi; Anachuna, Kenneth Kelechi; Moke, Emuesiri Goodies; Sanusi, Kamaldeen Olalekan; Okonofua, David Ehikhuemen; Omeru, Oghenerukevwe; and Fasanmade, Adesoji Adedipe
"High dietary salt intake alleviates fasting blood glucose in streptozotocin-induced diabetic male Wistar rats,"
The Thai Journal of Pharmaceutical Sciences: Vol. 45:
3, Article 2.
Available at: https://digital.car.chula.ac.th/tjps/vol45/iss3/2