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The Thai Journal of Pharmaceutical Sciences

Abstract

Objectives: Hypertension and type 2 diabetes are common comorbidities. Studies have shown that hypertension is twofold as common in diabetic patients compared with non-diabetics. Excessive intake of dietary salt has reportedly caused increase in blood pressure. This study investigated the effects of high dietary salt intake on diabetic rats. Materials and Methods: Twenty-eight animals were randomly selected into four groups (n = 7). Group 1 (normal control), fed with standard rats’ feed; Group 2 (diabetic control), streptozotocin-induced diabetic rats fed with normal diet; Group 3 (salt control), fed with 8% salt (high salt) diet; Group 4 (test group), streptozotocin-induced diabetic rats fed with high salt diet. Fasting blood glucose was monitored every 7 days. After 28 days of the study, blood pressure measurement was taken using tail cuff non-invasive method (CODA). Histology of the pancreas and kidney was done using hematoxylin and eosin staining. P < 0.05 was considered statistically significant. Results and Conclusion: Glucose levels of the test group reduced significantly when compared with the diabetic control group. This study suggests that high dietary salt intake plays a role, not only in reducing fasting blood glucose in a manner that is not yet understood but also causes distortion in the histomorphology of the pancreas and renal tissues.

Publisher

Faculty of Pharmaceutical Sciences, Chulalongkorn University

First Page

172

Last Page

177

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