The Thai Journal of Pharmaceutical Sciences


The goal of this research was to investigate the effect of electrolyte and an amphoteric surfactant on the viscosity, foamability, and foam stability of sodium laurylglucosides hydroxypropyl sulfonate (SLHS), a new anionic surfactant. Different concentrations of cocamidopropyl betaine (CAPB, 0–6% w/w) and sodium chloride (NaCl, 0–3% w/w) were added into 10% w/w SLHS solution. Each formulation was evaluated for its viscosity using a viscometer, whereas the foamability and foam stability were measured using the cylinder shaking method and analyzed by response surface methodology. The result demonstrated that an increased viscosity of the mixture resulted with an increased NaCl concentration over the tested range, and with an increased CAPB concentration up to 2% w/w, after which the viscosity was reduced with higher CAPB levels. The CAPB and NaCl were observed to have a significant effect on the foamability, but not with foam stability. No significant interaction effect between the CAPB and NaCl concentration occurred. However, the response surface models for both foaming characteristics presented a satisfactory determination coefficient, thus ensuring the precision and reliability of the models. Thus, the influence of CAPB and NaCl concentrations on SLHS solutions was well predicted and similar to other anionic surfactants.



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