The study of physical properties and formulation of self-assembling nanogel from grafted hydrophilic polymer backbone as stabilization system for curcumin

Authors

Penpimon Charoenkanburkang
Tisana Kaewruethai
Pornchai Rojsitthisak
Jittima Amie Luckanagul

Abstract

Introduction: The aim of this work is to formulate and study the thermoresponsive system with hyaluronic acid (HA) as a polysaccharide backbone grafted with poly-(N-isopropylacrylamide) (pNIPAM) for stabilization of highly sensitive molecule. Methods: The nanogel forming polymer was synthesized through EDC/NHS coupling reaction. The HA grafted pNIPAM (HA-g-pNIPAM) can be self-assembled to form gel particle. The synthesized HA-g-pNIPAM polymers were characterized by 1H NMR. Size, influence of media to forming nanogel, thermoresponsive behavior and influence of HA-g-pNIPAM nanogel network on curcumin loading capacity and stability were investigated by dynamic light scattering (DLS) and UV-VIS spectrophotometry. Result and Discussion: The results showed that the nanogel prepared in ultrapure water is appropriate to form nanogel with submicron-size range. The lower critical solution temperature (LCST) of HA-g-pNIPAM nanogels appeared at 33°C. This study also indicated the importance of polymer network as solubility and stability enhancer of curcumin which could be a model for other labile molecules or insoluble drugs.

Publisher

Faculty of Pharmaceutical Sciences, Chulalongkorn University

First Page

50

Last Page

53

Recommended Citation

Charoenkanburkang, Penpimon; Kaewruethai, Tisana; Rojsitthisak, Pornchai; and Luckanagul, Jittima Amie (2021) "The study of physical properties and formulation of self-assembling nanogel from grafted hydrophilic polymer backbone as stabilization system for curcumin," The Thai Journal of Pharmaceutical Sciences: Vol. 45: Iss. 1, Article 7.
Available at: https://digital.car.chula.ac.th/tjps/vol45/iss1/7