Evaluation of Anti-epileptic Activity of Lantana camara (Linn.) Flowers in Swiss Albino Mice

Authors

Kundan Singh Bora
Baldev Singh

Abstract

Introduction: Globally, approximately 50 million people are being affected by epilepsy and nearly 80% occurring in the developing countries. The plant Lantana camara Linn. (Family: Lamiaceae) is native to the tropical regions of the America, Africa, and Asia. It is found in Kumaon and Garhwal region of Uttarakhand, India. The plant has been used for various ailments in traditional systems of medicines for the treatment of epilepsy, wounds, tumor, stomach ache, and inflammation. Objective: The present study was planned with an objective to evaluate antiepileptic activity of L. camara flowers in mice. Methods: Maximum electric shock (MES) and pentylenetetrazoleinduced (PTZ) model of epilepsy were employed in the present study. Results: Among, the various extracts prepared, namely, petroleum ether, chloroform, ethanol and aqueous, pentylenetetrazoleinduced only ethanol and chloroform extract by successive solvent extraction method showed significant antiepileptic activity in MES and PTZ model of epilepsy. Highest antiepileptic activity (P < 0.05) was shown by ethanol extract at a dose of 200 mg/kg whereas chloroform extract showed moderate anticonvulsant effect at 200 mg/kg dose. Conclusion: The findings of present study lead to conclusion that ethanol extract of L. camara flowers showed potent antiepileptic activity which scientifically, validates the traditional claim of L. camara for the treatment of epilepsy.

DOI

10.56808/3027-7922.3053

Recommended Citation

Bora, Kundan Singh and Singh, Baldev (2025) "Evaluation of Anti-epileptic Activity of Lantana camara (Linn.) Flowers in Swiss Albino Mice," The Thai Journal of Pharmaceutical Sciences: Vol. 43: Iss. 4, Article 3.
DOI: https://doi.org/10.56808/3027-7922.3053
Available at: https://digital.car.chula.ac.th/tjps/vol43/iss4/3