The Thai Journal of Pharmaceutical Sciences
Abstract
Aim: The present work was aimed at formulating novel liquid self microemulsifying oil formulation and its solid form by spray drying method for improving the solubility of Ebastine, an antiallergic drug and BCS class II drug, evaluating its in vitro and in vivo potential. Results: The self emulsifying oil formulation was comprised of Rice Bran Oil, Tween 40, Capryol 90. Pseudoternary phase diagrams were used to evaluate the micro emulsification existence area, and the release rate of Ebastine was investigated using an in vitro dissolution test. Accelerated stability testing of the formulation was also assessed at 400C/75% RH for 3 months and the results showed that it was stable with respect to drug content and visual inspection. Group of mice were sensitized with intra peritoneal injections of ovalbumin. Starting from day 21, nasal symptoms were evaluated after mice were challenged with intranasal OVA administration. By counting the unit time of nasal rubbing and number of sneezing events for the duration of 10 minutes and the evaluation was carried out continuously for 10 days. Ebastine formulation was demonstrated to have antiallergic effects on the nasal symptoms of OVA induced mouse model. Conclusion: Ebastine formulation has the therapeutics potential for the treatment of allergic Rhinitis. The solid self emulsifying oil formulation is a promising dosage form for poorly water soluble and low bioavailable Ebastine.
DOI
10.56808/3027-7922.3046
Recommended Citation
Rajaram Mahajan, Vijay and Basarkar, Ganesh Dinkarrao
(2025)
"Formulation, characterization, and in vitro–in vivo evaluation of self microemulsifying drug delivery system of Ebastine by spray drying technology using solid carriers,"
The Thai Journal of Pharmaceutical Sciences: Vol. 43:
Iss.
3, Article 6.
DOI: https://doi.org/10.56808/3027-7922.3046
Available at:
https://digital.car.chula.ac.th/tjps/vol43/iss3/6
