Statistical Design, Formulation and Evaluation of Gastro Retentive Floating Tablets for Moxifloxacin using Natural and Semisynthetic Polymers

Authors

Raghavendra Kumar Gunda
A Vijayalakshmi

Abstract

Purpose: The objective of the current study is to develop gastroretentive formulation for moxifloxacin using various drug release modifiers, moxifloxacin, novel synthetic fluoroquinolone, and antibacterial agent. Materials and Methods: Floating tablets of moxifloxacin.HCl were prepared using variable amounts of hydroxypropyl methylcellulose (HPMC) K100M and lannea coromandelica gum (LCG) with effervescent mixtures as per 32 factorial designs by direct compression technique. Amount of release modifiers required to obtain the prolonged release of drug was chosen as independent variables, X1 and X2, respectively, whereas time taken for 10%, 50%, 75%, and 90% of drug release were chosen as dependent variables. Results and Discussion: Nine formulations were developed and are checked for pharmacopeial tests. Results show that all the factorial batches were lie within the standard limits. Dissolution parameters of all formulations were subjected to kinetic fitting; various statistical parameters were determined. Polynomial equations were developed and verified for dependent variables. Conclusion: Formulation (F5) containing 50 mg of HPMCK100M and 50 mg of LCG is the best formulation showing similarity f2 = 71.733 and f1 = 4.272 with the marketed product (AVELOX). Formulation F5 follows Higuchi’s kinetics, Non-Fickian Diffusion, and first-order kinetics (n = 1.098).

DOI

10.56808/3027-7922.3045

Recommended Citation

Gunda, Raghavendra Kumar and Vijayalakshmi, A (2025) "Statistical Design, Formulation and Evaluation of Gastro Retentive Floating Tablets for Moxifloxacin using Natural and Semisynthetic Polymers," The Thai Journal of Pharmaceutical Sciences: Vol. 43: Iss. 3, Article 5.
DOI: https://doi.org/10.56808/3027-7922.3045
Available at: https://digital.car.chula.ac.th/tjps/vol43/iss3/5