Various NMDAR antagonists decrease interferon-alpha induced depression behavior in mice model of despair

Authors

Azadeh Mesripour
Ahmad Purhasani
Valiollah Hajhashemi

Abstract

Introduction: Treatment with interferon-alpha (IFNa) can induce depression that is likely the result of its effect on the tryptophan–kynurenine pathway. Kynurenine passes through the blood-brain barrier and breaks to neurotoxic metabolites, such as qui...

Publisher

Faculty of Pharmaceutical Sciences, Chulalongkorn University

First Page

8

Last Page

13

Recommended Citation

Mesripour, Azadeh; Purhasani, Ahmad; and Hajhashemi, Valiollah (2019) "Various NMDAR antagonists decrease interferon-alpha induced depression behavior in mice model of despair," The Thai Journal of Pharmaceutical Sciences: Vol. 43: Iss. 1, Article 2.
Available at: https://digital.car.chula.ac.th/tjps/vol43/iss1/2