The Thai Journal of Pharmaceutical Sciences
Abstract
This report is concerned with the production of granules from powdered sugar-tapioca starch mixtures by fluidized bed granulation technique. The application of such granules as direct compression vehicles in manufacture of tablets products was demonstrated. The mixtures of powdered sugar-tapioca starch in the ratio of 1:1 were employed to prepare the granules using polyvinylpyrrolidone and gelatin as the granulating agents. Successful granulation of sugar-starch mixtures in a fluidized bed granulator were attained to have porous, irregular shape granules with narrow size distribution and low density. The physical properties of granular products using two binders were different. The finished granules were used to produce diazepam and chlorpheniramine maleate tablets by direct tabletting after blending with the drug powders. The tablet products exhibited satisfactory properties and complied with the compendial requirements.
DOI
10.56808/3027-7922.3308
First Page
81
Last Page
91
Recommended Citation
Kulvanich, Poj and Prechagoon, Detpon
(1995)
"The application of powdered sugar-tapioca starch granules prepared by Fluidized bed granulation technique in direct tableting process,"
The Thai Journal of Pharmaceutical Sciences: Vol. 19:
Iss.
2, Article 2.
DOI: https://doi.org/10.56808/3027-7922.3308
Available at:
https://digital.car.chula.ac.th/tjps/vol19/iss2/2