The Thai Journal of Pharmaceutical Sciences
Abstract
In vitro permeation behaviors of a synthetic membrane, Silastic™, and a biological membrane, newborn pig skin, were characterized using piroxicam as a model drug. Experiments had been carried out using modified Franz diffusion cells. Various gel bases containing 2% piroxicam were prepared to study the in vitro permeation of the drug. Gelling agents studied were Pluronic F127, Carbopol 940, hydroxypropyl methylcellulose and hydroxyethyl cellulose. Piroxicam fluxes from the four gel bases through SilasticT were correlated with the fluxes through pig skin with the r2 of 0.96. The Carbopol 940 gel base yielded the highest flux. It was, therefore, used for further study of effects of some additives on the steady state flux of piroxicam. The additives studied included 10% and 20% isopropyl alcohol, 5% and 10% propylene glycol, and 0.5% and 1.0% Tween 20. Consequently, SilasticTM could replace pig skin for diffusion rate comparison of gel preparations containing components which did not have any effects on the membranes.
DOI
10.56808/3027-7922.3307
First Page
13
Last Page
26
Recommended Citation
Vayumhasuwan, Panida and Polpakdee, Busaba
(1995)
"Comparison of piroxicam flux from gel preparations through polydimethylsiloxane membrane and pig skin,"
The Thai Journal of Pharmaceutical Sciences: Vol. 19:
Iss.
1, Article 6.
DOI: https://doi.org/10.56808/3027-7922.3307
Available at:
https://digital.car.chula.ac.th/tjps/vol19/iss1/6