Association between nutritional status with serum low-density lipoprotein (LDL) level and triglycerides (TG) level among adolescents in Yogyakarta, Indonesia

Authors

Bambang Edi Susyanto, Doctorate Program of Medical Science, Faculty of Medicine Universitas Sebelas Maret, Surakarta, IndonesiaFollow
Harsono Salimo, Department of Pediatrics, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
Bambang Purwanto, Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
Eti Poncorini Pamungkasari, Department of Medical Education, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
Soetrisno Soetrisno, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia

Abstract

Background: Triglycerides (TG) and high-density lipoprotein (HDL) levels were significantly higher in children and adolescents with dyslipidemia. Elevated low-density lipoprotein (LDL) levels have been linked to clinical cardiovascular disease. This study aimed to examine the relationship between serum TG and LDL cholesterol levels with nutritional status in adolescents.

Methods: This observational, cross-sectional study was carried out from December 2021 to April 2022. The research participants were 145 teenagers aged 13–18 years old living in the Special Region of Yogyakarta, Indonesia. Participants were chosen by consecutive sampling. At baseline, each participant’s nutritional status and TG and LDL serum levels were measured. Using CDC body mass index guidelines for teenagers, we assessed the nutritional status of all the participants and divided them into 2 groups (normal versus obese/overweight).

Results: Borderline and high levels of LDL were found in 33 participants (22%) in the obese/overweight group; in addition, in the obese/overweight group, 38 participants (26%) had borderline or high TG levels. Based on a chi-square test, there was a statistically significant relationship between serum LDL levels and the nutritional status of adolescents (p = 0.009). The difference in serum TG levels based on nutritional status was not statistically significant (p = 0.081).

Conclusion: There was a positive relationship between nutritional status and serum LDL levels, but not TG levels. Serum levels of LDL can be used as cardiometabolic markers associated with obesity and overweight status among adolescents.

Keywords: obesity, dyslipidemia, nutritional status, adolescents

Recommended Citation

Susyanto B, Salimo H, Purwanto B, Pamungkasari E, Soetrisno S. Association between nutritional status with serum low-density lipoprotein (LDL) level and triglycerides (TG) level among adolescents in Yogyakarta, Indonesia. J Health Res. 2024; 38(3):-. DOI: https://doi.org/10.56808/2586-940X.1082

References

[1] Mahdiah M, Hadi H, Susetyowati S. Prevalensi obesitas dan hubungan konsumsi fast food dengan kejadian obesitas pada remaja SLTP kota dan desa di Daerah Istimewa Yogyakarta. J Gizi Klin Indones. 2004 Nov 1;1(2):69.

[2] NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet. 2017 Dec 16;390(10113):2627-2642. doi: 10.1016/S0140-6736(17)32129-3

[3] Suryaputra K, Nadhiroh SR. Perbedaan Pola Makan dan Aktivitas Fisik antara Remaja Obesitas dengan non Obesitas. 2012;16(1):6.

[4] Putra DA, Salimo H, Andarini I. Hubungan Parameter Antropometri dengan Nilai Arus Puncak Ekspirasi pada Remaja di Surakarta. Sari Pediatri. 2019 May 16;20(6):349.

[5] Nuraini A, Murbawani EA. Hubungan antara Ketebalan Lemak Abdominal dan Kadar Serum High Sensitivity C-Reactive Protein (Hs-Crp) pada Remaja. J Nutr Coll. 2019 May 14;8(2):81.

[6] Indonesia, Ministry of Health of Indonesia. Basic health research 2018. [cited 2022 Nov]. Available from: https://kesmas.kemkes.go.id/assets/upload/dir_519d41d8cd98f00/files/Hasil-riskesdas-2018_1274.pdf

[7] Hadi H. Gizi lebih sebagai tantangan baru dan implikasinya terhadap kebijakan pembangunan kesehatan nasional. J Gizi Klin Indones. 2004 Nov 1;1(2):47.

[8] Rahim MA, Sadiyah H, Deasinta Y, Angriani A. OISHI (Obesity Home Care Intervention) sebagai Inovasi Rumah Rawat Mandiri Obesitas untuk Meningkatkan Kualitas Hidup Anak Penderita Obesitas. BIMIKI Berk Ilm Mhs Ilmu Keperawatan Indones. 2020 Feb 27;6(2):9–17.

[9] Pulungan AB, Marzuki ANS, Julia M, Rosalina I, Damayanti W, Yunarso PB, et al. Konsensus Ikatan Dokter Anak Indonesia. [cited 2022 Nov]. Available from: https: www.idaioridprofessional-Resour-Konsensusdiagnosis-Tata-Laksana-Dan-Pencegah-Obesitas-Pada-Anak-Dan-Remaja. 2014;22.

[10] Taylor RW, Cox A, Knight L, Brown DA, Meredith-Jones K, Haszard JJ, et al. A Tailored Family-Based Obesity Intervention: A Randomized Trial. Pediatrics. 2015 Aug;136(2):281-9. doi: 10.1542/peds.2015-0595.

[11] Friend A, Craig L, Turner S. The prevalence of metabolic syndrome in children: a systematic review of the literature. Metab Syndr Relat Disord. 2013 Apr;11(2):71-80. doi: 10.1089/met.2012.0122.

[12] Laksana T. Ikatan Dokter Anak Indonesia. [cited 2022 Nov]. Available from: https: www.idaioridprofessional-Resour-Konsensusdiagnosis-Tata-Laksana-Dan-Pencegah-Obesitas-Pada-Anak-Dan-Remaja. 2014.

[13] Demerdash HM. Role of Oxidative Stress and Associated Alteration in Enzyme Activities in Obesity Comorbidities. Obes Res Open J. 2017 Dec 28;4(2):32–43.

[14] Marseglia L, Manti S, D'Angelo G, Nicotera A, Parisi E, Di Rosa G, Gitto E, Arrigo T. Oxidative stress in obesity: a critical component in human diseases. Int J Mol Sci. 2014 Dec 26;16(1):378-400. doi: 10.3390/ijms16010378.

[15] Castro AM, Macedo-de la Concha LE, Pantoja-Meléndez CA. Low-grade inflammation and its relation to obesity and chronic degenerative diseases. Rev Médica Hosp Gen México. 2017 Apr;80(2):101–5.

[16] Bravo PE, Morse S, Borne DM, Aguilar EA, Reisin E. Leptin and hypertension in obesity. Vasc Health Risk Manag. 2006 Apr;2(2):163–9.

[17] Shah SZA, Devrajani BR, Devrajani T, Bibi I. Frequency of Dyslipidemia in Obese Versus Non - Obese in Relation to Body Mass Index (BMI), Waist Hip Ratio (WHR) and Waist Cirfumference (WC). Pak J Sci. 2010;62(1).

[18] Snedecor GW, Cochran WG. Statistical Methods. 6th ed. Ames: Lowa State University; 1967.

[19] Lemeshow S, Hosmer Jr DW, Klar J, Lwanga SK. Besar Sampel Dalam Penelitian Kesehatan [Sample Size in Health Research]. Yogyakarta : Gadjah Mada University Press; 1997.

[20] Lozano P, Henrikson NB, Morrison CC, Dunn J, Nguyen M, Blasi PR, et al. Lipid Screening in Childhood and Adolescence for Detection of Multifactorial Dyslipidemia: Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA. 2016 Aug 9;316(6):634-44. doi: 10.1001/jama.2016.6423.

[21] Mardiah A. Hubungan Profil Lipid Darah dengan Kejadian Obesitas Sentral pada Pasien Dewasa yang Memeriksakan Profil Lipid Darah di Balai Laboratorium Kesehatan Provinsi Sumatera Barat Tahun 2018. Politek Kesehat Kemenkes Padang. 2018;80.

[22] Kaniawati M, Sukmawati IK, Manik TN. Hubungan antara Obesitas dengan Profil Kolesterol LDL, Apolipoprotein B dan small dense LDL pada Remaja. 2019;6:10.

[23] Farizal J, Marlina L. Hubungan Kadar Trigliserida dengan Mahasiswa Obesitas. Avicenna J Ilm. 2019 Sep 18;14(02):42–6.

[24] Tandra HJR, Bodhi W, Kepel BJ. Perbedaan profil lipid pada remaja obes dan tidak obes di Kecamatan Bolangitang Barat. J E-Biomedik [Internet]. 2016 Dec 13 [cited 2022 Jun 2];4(2). Available from: https://ejournal.unsrat.ac.id/index.php/ebiomedik/article/view/14266

[25] Anggraeni F. Hubungan antara Obesitas Sentral dengan Kadar Kolesterol LDL dan Kadar Trigliserida pada Pasien Poli Rawat Jalan Ilmu Penyakit Dalam RSU Dr. Saiful Anwar Malang. 2009;1.

[26] Subandrate S, Sinulingga S, Zulissetiana EF, Susilawati S, Setyorini DI, Amalia E. Korelasi antara indeks massa tubuh dan profil lipid pada remaja obesitas di kota Palembang. Maj Kedokt Andalas. 2020 Nov 15;43(2):105.

[27] Cook S, Kavey REW. Dyslipidemia and Pediatric Obesity. Pediatr Clin North Am. 2011 Dec;58(6):1363–73.

[28] Klop B, Elte JW, Cabezas MC. Dyslipidemia in obesity: mechanisms and potential targets. Nutrients. 2013 Apr 12;5(4):1218-40. doi: 10.3390/nu5041218.

[29] Hazer, İ., Kabukçu, H. O., Yağcı, M., Ertürk, Z., Yıldırım, G. K., & Kirel, B. (2020). The association of lipid metabolism and non-alcoholic fatty liver disease in children with obesity. Turk pediatri arsivi, 55(3), 263–269. [Internet]. 2020 [cited 2023 Feb 6]; Available from: http://turkarchpediatr.org//en/the-association-of-lipid-metabolism-and-non-alcoholic-fatty-liver-disease-in-children-with-obesity-1356

[30] Friedland, O., Nemet, D., Gorodnitsky, N., Wolach, B., & Eliakim, A. (2002). Obesity and lipid profiles in children and adolescents. Journal of pediatric endocrinology & metabolism : JPEM, 15(7), 1011–1016. [Internet]. 2002 Jan [cited 2023 Feb 6];15(7). Available from: https://www.degruyter.com/document/doi/10.1515/JPEM.2002.15.7.1011/html

[31] Jung MK, Yoo EG. Hypertriglyceridemia in Obese Children and Adolescents. J Obes Metab Syndr. 2018 Sep 30;27(3):143-149. doi: 10.7570/jomes.2018.27.3.143.