Effectiveness of Vitamin D3 in Facilitating the Therapeutic Progression of Healing Diabetic Foot Ulcers

Authors

Fatemeh Nouri, Department of Biology, School of Basic Sciences, Science and Research Branch, Islamic Azad University (SRBIAU), Tehran, IranFollow
Sara Aghaei, Department of Dermatology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IranFollow
Gülüzar Özbolat, Faculty of Health Science, Sinop University, Sinop, TurkeyFollow
Yusuf Döğüş, Department of Medical Biochemistry, Faculty of Medicine, Cukurova University, Adana, TurkeyFollow
Mahdi Mirhamidi, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, IranFollow
Reza Rahimi Barghani, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, IranFollow
Amin Daemi, Department of Medical Biochemistry, Faculty of Medicine, Cukurova University, Adana, TurkeyFollow

Abstract

Background: Today’s, diabetes and its complications have afflicted a large population all over the world, so that it is estimated that its prevalence in all age groups will reach from 2.8% in 2000 to 4.4% in 2030. It is well known that vitamin D may cause rapid wound healing and anti-inflammatory.

Objective: Regarding the importance of the quality of life of diabetic patients and the improvement of chronic diabetic foot ulcers, this paper aims to investigate the efficacy of vitamin D3 on the healing of diabetic foot ulcers. The present research is conducted as a randomized controlled trial.

Methods: Forty patients are randomly divided into two experimental groups (vitamin D supplementation) and control (placebo) using available sampling method based on the inclusion criteria. Then, all patients are evaluated for ulcer debridement every two weeks (0 (T0), 2 (T1), 4 (T2), 6 (T3), 8 (T4), 10 (T5) and 12 (T6)) after the intervention. The collected data are analyzed using SPSS-23 software.

Results: The experimental group significantly decreased the ulcer length (-1.6±0.82 cm vs. -0.5 ± 1.39 cm, P = 0.005), ulcer width (-1.7±1.20 cm vs. -0.85 ± 1.22 cm, P = 0.025) and ulcer depth (-0.6±0.50 cm vs. -0.25 ± 0.44 cm, P = 0.025), after 12 weeks of intervention. It can be seen that Vitamin D had a significant relationship with all stages of the wound-healing process (P<0.01).

Conclusions: In patients with chronic diabetic foot ulcers, the use of vitamin D supplementation can improve the wound. Moreover, vitamin D had a significant relationship with all stages of the wound-healing process except re-epithelialization and angiogenesis.

DOI

10.56808/2673-060X.5608

First Page

1

Last Page

14

Recommended Citation

Nouri, Fatemeh; Aghaei, Sara; Özbolat, Gülüzar; Döğüş, Yusuf; Mirhamidi, Mahdi; Rahimi Barghani, Reza; and Daemi, Amin (2025) "Effectiveness of Vitamin D3 in Facilitating the Therapeutic Progression of Healing Diabetic Foot Ulcers," Chulalongkorn Medical Journal: Vol. 69: Iss. 5, Article 4.
DOI: https://doi.org/10.56808/2673-060X.5608
Available at: https://digital.car.chula.ac.th/clmjournal/vol69/iss5/4