Abstract
Background: Schizophrenia has been increasingly linked to inflammation. The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) have emerged as potential indicators of systemic inflammation.
Objectives: The objectives are to compare NLR, MLR, and PLR between patients with schizophrenia and healthy controls, and to investigate the factors associated with NLR. Methods: This retrospective study included 102 sex- and age-matched patients hospitalized with schizophrenia and control subjects. NLR, MLR, and PLR were calculated from the Complete Blood Count (CBC) results and compared between groups. Sociodemographic data and clinical characteristics were analyzed using multiple linear regression to identify factors associated with the NLR in patients with schizophrenia. Results: NLR and MLR of acute schizophrenia patients were found to be significantly higher when compared with the control group (2.98 ± 2.02 vs 1.79 ± 0.78, p < 0.01 and 0.25 ± 0.11 vs 0.18 ± 0.07, p < 0.01, respectively). PLR was not significantly different between the two groups (152.13 ± 70.75 vs 143.09 ± 49.1, p = 0.290). First-episode illness was the only factor associated with a higher NLR (p < 0.05) in schizophrenia.
Conclusion: Higher NLR and MLR values found in hospitalized patients with schizophrenia support the inflammatory hypothesis of schizophrenia.
DOI
10.56808/2673-060X.5536
First Page
1
Last Page
20]
Recommended Citation
Dangrungroj, Apichan and Chiddaycha, Mayteewat
(2025)
"Neutrophil-to-Lymphocyte, Monocyte-to-Lymphocyte, and Platelet-to-Lymphocyte Ratio in Acute Hospitalized Patients with Schizophrenia,"
Chulalongkorn Medical Journal: Vol. 69:
Iss.
4, Article 7.
DOI: https://doi.org/10.56808/2673-060X.5536
Available at:
https://digital.car.chula.ac.th/clmjournal/vol69/iss4/7
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