Exploring the Therapeutic Potential of Trigonella foenum-graecum Extract-Loaded Transferosomal Gel in Freund's Complete Adjuvant-Induced Rat Models.

Authors

Vandana Singh Ms., School of Pharmacy, Sharda University, Greater Noida, India.Follow
Hema Arya Ms., School of Pharmacy, Sharda University, Greater Noida, India.Follow
Bhavana Singh Dr., Department of Pharmacy, Sharda University, Greater Noida, India.Follow
Koushal Dhamija Mr., Department of Pharmaceutics, Lloyd Institute of Management and Technology, Greater Noida, India.Follow
Preeti Singh Dr., School of Pharmacy, Sharda University, Greater Noida, India.Follow
Gautam Kumar Dr., School of Pharmacy, Sharda University, Greater Noida, India.Follow

Abstract

Abstract:

Background: Rheumatoid arthritis (RA) is a debilitating autoimmune disorder characterized by inflammation and joint damage.

Objective: This study aimed to evaluate the antiarthritic activity of Trigonella foenum-graecum (TFG) Transferosomal gel in a Freund’s adjuvant-induced arthritic rat model and compare it with Diclofenac gel, a standard anti-inflammatory drug.

Methods: Arthritis was induced in rats by injecting a 0.1 mL (1mg/ml) CFA suspension into the left hind foot in the subplantar region, allowing them to develop arthritis for 21 days.

Results: Arthritis induction led to a significant increase in paw volume, indicative of inflammation. Treatment with both TFG-transferosomal gel and Diclofenac gel significantly reduced paw volume, demonstrating their anti-inflammatory effects. Additionally, TFG-transferosomal gel reduced arthritic scores, indicating its potential to ameliorate arthritic symptoms. Both treatments also improved locomotor activity, suggesting relief from pain-induced hypoactivity. Furthermore, biochemical analysis revealed that TFG-transferosomal gel effectively reduced inflammatory enzyme activity and mediator levels, comparable to Diclofenac gel.

Conclusion: These results demonstrate the anti-inflammatory efficacy of TFG-transferosomal gel, highlighting its potential as a therapeutic option for managing arthritis-associated inflammation and symptoms. Further research is warranted to elucidate its mechanisms of action and assess its clinical utility.

DOI

10.56808/2673-060X.5477

First Page

Introduction

Last Page

References

Recommended Citation

Singh, Vandana Ms.; Arya, Hema Ms.; Singh, Bhavana Dr.; Dhamija, Koushal Mr.; Singh, Preeti Dr.; and Kumar, Gautam Dr. (2025) "Exploring the Therapeutic Potential of Trigonella foenum-graecum Extract-Loaded Transferosomal Gel in Freund's Complete Adjuvant-Induced Rat Models.," Chulalongkorn Medical Journal: Vol. 69: Iss. 2, Article 2.
DOI: https://doi.org/10.56808/2673-060X.5477
Available at: https://digital.car.chula.ac.th/clmjournal/vol69/iss2/2