Background : Osteoarthritis (OA) is a degenerative articular disease that involves progressive alterations in all joint structures resulting from aging and overuse activity. Leptin and vitamin D play a crucial role in energy metabolism; however, few reports on leptin and 25-hydroxyvitamin D (25(OH)D) in knees of osteoarthritis (OA) has been known.Objectives : To examine serum levels of leptin and vitamin D in knee OA patients and analyze the possible relationship between serum leptin, 25-hydroxyvitamin D, and clinical parameters in OA patients.Methods : In a cross-sectional study, 235 adult patients (212 women and 23 men, aged 65.6 6.5 years) with established diagnosis of OA and 50 healthy controls were recruited. Serum 25(OH)D and serum leptin levels weremeasured.Results : Serum vitamin D insufficiency ( 30 ng/ml) was found in 48.0% of the patients with OA; whereas serum vitamin D deficiency ( 20 ng/ml) was detected in 35.0% of osteoarthritis patients. Serum leptin concentrations were significantly elevated in OA patients when compared with the controls (P = 0.02). There was a negative correlation between serum 25(OH)D concentration and serum leptin in patients with knee OA (P < 0.001) (r = -0.26, P < 0.001).Conclusions : Vitamin D insufficiency and deficiency is highly prevalent in OA patients and associated with higher serum leptin. These findings suggest that high serum leptin could be used for predicting low vitamin D in kneeOA patients.
Faculty of Medicine, Chulalongkorn University
Manoy, Pacharee; anomasiri, Wilai; Yuktanandana, Pongsak; Tanavalee, Aree; Mabey, Thomas; and Honsawek, Sittisak
"Relationship of serum leptin and 25-hydroxyvitamin D in knee osteoarthritis patients,"
Chulalongkorn Medical Journal: Vol. 62:
6, Article 12.
Available at: https://digital.car.chula.ac.th/clmjournal/vol62/iss6/12