Chulalongkorn Medical Journal


Background : Although the results of several studies support the safety of livekidney donation, there is no functional deterioration, some donorshave proteinuria and hypertension (HT). Most of the studieswere done in Europe and America, in Asia, however, theinformation about donors living with one kidney is lacking.Objective : To study the long-term risks of chronic kidney disease (CKD) inliving kidney donors at one medical center in Thailand.Design : A retrospective study.Setting : Division of Urology, Department of Surgery, Faculty of Medicine,Chulalongkorn University, Bangkok, Thailand.Materials and Methods : Donors who were followed up for more than 1 year afternephrectomy were included. We assessed each donor’s bloodpressure, urine protein, and estimated glomerular filtration rate(eGFR).Results : The donors had a mean age of 37.5 ± 9.78 years at donation.The median follow-up period was 3.62 years (range 1 - 11 yrs ).There were statistically significant increases in SBP from 113.3 ±11.15 to 120.5 ± 11.99 mm Hg. and BMI from 22.9 to 23.6(P <0.001). 4 (4.7%) developed hypertension and 2 (2.3%)displayed proteinuria. Serum Cr significantly changed from0.72 ± 0.2 to 1.02 ± 0.22 mg/dL. (P <0.001) and eGFR from114.6 ± 36.62 to 74.26 ± 14.46 mL/min/1.73 m². (P <0.001)5(5.8%) had CKD (eGFR<60 mL/min/1.73 m²). Aftertransplantation, eGFR decreased by < 1 mL/min/1.73 m² eachyear. Age at donation and longer follow-up time were significantrisk factors for renal functional deterioration (CKD, HT, proteinuria)(P = 0.04, OR = 1.092 (1.004 - 1.188) and P = 0.012,OR = 1.425 (1.079 - 1.881), respectively).Conclusion : Renal function was well preserved after donor nephrectomy inearly period. A significant proportion of living donors mightdevelop renal deterioration upon long-term follow-up.


Faculty of Medicine, Chulalongkorn University

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