Chulalongkorn Medical Journal


MDS is a group of abnormality in hematologic stem cells characterized by ineffective hematopoiesis and various clinical presentations. Treatment of MDS is costly, and may not be possible in most areas in Thailand. Valproic acid (VPA) is used for the treatment of convulsion with low adverse reaction. It can also act as histone deacetylase inhibitor, and can be administered orally. The study of treatment of MDS patients with VPA alone or in combination with other drugs, the dose was adjusted to get serum concentration 50 - 100 μg/mL. found that the responses was quite good in hematologic improvement and reduction in blood transfusion. The use of VPA in the treatment of MDS is safely and efficacy.


Faculty of Medicine, Chulalongkorn University

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