Chulalongkorn Medical Journal


C. Sukasem


Human polymorphic nature has an effect on individual drug response and adverse drug reactions (ADR). These variations include insertions, deletions, copy number variations and single nucleotide polymorphisms (SNPs) that affect gene expression and activity of drug metabolizing enzymes. Currently, there have been extensively studies and well characterized relationships between genetic variations and drug metabolism, and drug toxicity. Consequently, the application of patient genetic background to individualized therapy has been achieved at the practical level. Moreover, information on pharmacogenetics will be a crucial factor in medical practices in the near future. Therefore, the focus of this article will be on recent evidence on pharmacogenetic markers involved in drug response and doses appropriate, clinical application and impact on medical economy. It is expected that a wider understanding of existing evidence by medical profession is essential to increase their utilization.



First Page


Last Page




To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.