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The Thai Journal of Pharmaceutical Sciences

Abstract

Objective: The goal of this study was to evaluate the alone or associated spinach, zinc, and ω-3/Vitamin E capacity to improve the renal function and bone calcification altered by fluoride in Wistar rats. Methods: In this study, 36 female Wistar albino rats were used; divided into six groups (n = 6); all groups except the control rats received orally 400 ppm of fluoride as sodium fluoride (NaF) in drinking water during 70 days and then four groups treated in the past 15 days by: Spinach powder, zinc, ω-3/Vitamin E, and spinach+ zinc + ω-3/Vitamin E. Some biochemical and histological markers were analysis. Results: Exposure to fluoride altered significantly (P < 0.05) the kidney function and structure, calcium status, and induced kidney oxidative stress by decreasing glutathione (56%) and increasing the Malondialdehyde (26%) levels compared to control. Treatments with spinach enriched with zinc and ω 3 modulate calcium levels, kidney oxidative stress status, and attenuate kidney histological disturbance Conclusion: Single or interactive treatments administration exhibited a significant normalized effect on bone calcification disturbance, histological alterations, and oxidative stress state in the rats kidney induced by NaF

Publisher

Faculty of Pharmaceutical Sciences, Chulalongkorn University

First Page

674

Last Page

681

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