Solubility enhancement of diacerein by spray drying technique, formulation development, and in vivo study

Authors

Devidas G. Bachhav
Somashekhar S. Khadabadi
Leena P. Deore
Vilas B. Ghavate

Abstract

Purpose: The aim of the present research was solubility and dissolution rate enhancement of diacerein by spray drying technique. Materials and Methods: Solid dispersions of diacerein with PEG-600, guar gum, poloxamer-188 and aerosil were prepared in different ratios using 32 factorial designs. FTIR, DSC, XRD and SEM were performed to study the interaction between drug and polymers and evaluated for in-vitro drug release study. Results and Discussion:In spray dried solid dispersion formulations there was decrease in crystallinity of diacerein, which leads to increase in dissolution of diacerein from solid dispersions. Diacerein 50 mg immediate release tablets formulated (using spray dried solid dispersion formulation which shows maximum drug release) by 32 factorial design to study effect of binder (PVPK-30) and disintegrant (Crospovidone) concentration on disintegration and dissolution of diacerein. Formulation showed better analgesic and anti-inflammatory activity and increase in bioavailability. Conclusion: Spray drying found to be effective technique to improve solubility, dissolution and bioavailability of poorly water-soluble drugs.

Publisher

Faculty of Pharmaceutical Sciences, Chulalongkorn University

First Page

660

Last Page

673

Recommended Citation

Bachhav, Devidas G.; Khadabadi, Somashekhar S.; Deore, Leena P.; and Ghavate, Vilas B. (2023) "Solubility enhancement of diacerein by spray drying technique, formulation development, and in vivo study," The Thai Journal of Pharmaceutical Sciences: Vol. 46: Iss. 6, Article 6.
Available at: https://digital.car.chula.ac.th/tjps/vol46/iss6/6