The Thai Journal of Pharmaceutical Sciences
Abstract
Hepatoprotective and antioxidant potential of hydromethanolic extract of Rivina humilis L. fruit (HMERH) was studied using the carbon tetrachloride (CCl4) and paracetamol (PCM) induced hepatotoxicity in Wistar rats. In both models, rats were divided into five groups having six rats in each. Group I received distilled water. Group II, disease control, Group III received 100 mg/kg of Silymarin. Group IV and Group V received 500, 1000 mg/kg of HMERH. All groups except Group II received treatment twice daily for 7 days. CCl4 (1.5 mL/kg, PCM (2 g/kg), p.o) were administered after the last dose. The degree of liver protection against toxicity was measured by estimating serum liver marker enzymes and protein. In addition, estimation of lipid profile, liver weight, and histopathological examination were done. Peroxidase (P), Catalase, glutathione, total protein, superoxide dismutase, and malondialdehyde were also estimated from the part of liver isolated. HMERH 500 and 1000 mg/kg treated groups showed a significant (P < 0.001) decrease in serum marker enzymes as well as total bilirubin levelswere also restored. It also stabilize and restored the lipid profile and endogenous antioxidant enzyme system. Hence, the hepatoprotective effect of HMERH 500 and 1000 mg/kg against CCl4 as well as PCM may possibly be mediated through antioxidant activity.
Publisher
Faculty of Pharmaceutical Sciences, Chulalongkorn University
First Page
653
Last Page
659
Recommended Citation
Asirvatham, Raju; George, Dinu; Daisy, P. A.; Tomy, Dawn V.; and Johns, G. Boby
(2023)
"Preclinical study on hepatoprotective potential and antioxidant status analysis of the fruit extract of Rivina humilis L. (red pigeon berry) in rats,"
The Thai Journal of Pharmaceutical Sciences: Vol. 46:
Iss.
6, Article 5.
Available at:
https://digital.car.chula.ac.th/tjps/vol46/iss6/5