The Thai Journal of Pharmaceutical Sciences
Abstract
Background: Since severe acute respiratory syndrome coronavirus 2 causing coronavirus disease 2019 pandemic has emerged, various air membrane filters with antimicrobial agents have been explored and investigated for inactivating virus particles. Objectives: The purpose of this study was to determine an antiviral activity of the air filter coated with silver ions using the method of ISO 21702:2019. Materials and Methods: Herpes simplex virus type 1 (HSV-1), KOS strain, an enveloped virus causing skin, mucous membrane, and respiratory tract infection (RTI) were tested with the non-porous surface coated with or without silver ions (control filter) for 0, 24 h at 25°C. The viral infectivity titers were determined on Vero cells by a plaque assay. After 24 h, the silver filter showed high anti-viral effect with logarithmic reduction >3.91 or 99.92% reduction compared to that of the control filter. Validation of the method demonstrated that the filters were nontoxic, the cell was sensitive to the virus and the neutralizer could inactivate the antiviral activity. Conclusion: The air filter coated with silver ions possessed anti-HSV-1activity. Further study with other viruses causing RTI would be helpful for the prevention of viral spread.
Publisher
Faculty of Pharmaceutical Sciences, Chulalongkorn University
First Page
734
Last Page
739
Recommended Citation
Wirotesangthong, Mali; Khanboon, Ariya; and Piewpong, Kanyanat
(2023)
"Determination of anti-herpes simplex virus type 1 activity of the air filter coated with silver ions using a modified method of ISO 21702:2019,"
The Thai Journal of Pharmaceutical Sciences: Vol. 46:
Iss.
6, Article 13.
Available at:
https://digital.car.chula.ac.th/tjps/vol46/iss6/13