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The Thai Journal of Pharmaceutical Sciences

Abstract

There is considerable interest in herbal medicine in developing antidiabetic alternative therapy based on plant-derived compounds that would reduce oral hypoglycemic agent-related adverse effects while staying safe during pregnancy. The purpose of this in vivo study was to evaluate the ethanolic extract of Chromolaena odorata L. leaves (ECOL) in alloxan-induced diabetes and its teratogenic effect. The hypoglycemic impact of ECOL increased when the extract dose was raised. Three doses of ECOL (125, 250, and 500 mg/kg body weight) showed a 27.29%, 34.68%, and 52.24% hypoglycemic effect, respectively. While, the standard insulin (1 IU/kg BW) group shown a 31.38% hypoglycemic effect (P < 0.05). The ECOL groups improved beta-cells in the islets of Langerhans in histological examinations of the pancreas. The ECOL groups showed no influence on fetal mortality, however, had a substantial impact on the fetal ossification process (P < 0.05) in the teratogenic study.

Publisher

Faculty of Pharmaceutical Sciences, Chulalongkorn University

First Page

561

Last Page

569

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