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The Thai Journal of Pharmaceutical Sciences

Abstract

Objective: Scopoletin is one of the dynamic and active constituents originate in Canscora decussata (CD) herb from Shankhpushpi family according to Indian system of medicine. This study aimed to characterize and to explore the role of scopoletin enriched CD (SECD) extract on AlCl3-induced neuroinflammation and excitotoxicity in rat model. Methodology & Results: High-performance thin-layer chromatography finger printing of ethanol extract of CD confirmed that enriched scopoletin presence as its main constituent. AlCl3 induced behavioural changes were reversed after SECD (200 and 400 mg/kg, i. p) and Rivastigmine (0.3 mg/kg, i.p) treatment by the way of Y maze, Rota rod, and grip strength experiments. SECD was investigated for anti acetylcholinesterase activity associated to memory and motor impairment. In addition to that, AlCl3-induced inflammation and neurotoxicity was reversed significantly after SECD administration as it alleviates the rise of TNFα, IL-1β, and IL-6 release and the suppression of striatal glutamate and aspartate action. Further, our finding shows that AlCl 3-induced subcellular alterations include gliosis and lymphocytic infiltration in the cerebral cortex, as well as neuronal cell death, vacuolation, and cell membrane rupture in the hippocampus. Conclusion: This study concludes that treatment with SECD can be a novel phytochemical molecule for the retrieval of memory and motor impairment by preserving cholinergic and glutaminergic regulations, and to maintain the central morphological integrity.

Publisher

Faculty of Pharmaceutical Sciences, Chulalongkorn University

First Page

533

Last Page

540

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