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The Thai Journal of Pharmaceutical Sciences

Abstract

Background: Synergism is a well-known concept in Herbal therapies. Polyherbal aqueous extract (PH-AE) containing Gymnema sylvestre (GS), Momordica charantia, Syzygium cumini, and Mangifera indica was evaluated for Antidiabetic activity. Objective: In our continuous research, an attempt has been made to explore GS aqueous extract (GS-AE) and its Polyherbal composite for diabetes to achieve greater efficacy. Methods: The antidiabetic activity was assessed in Streptozotocin induced diabetic rats and histopathological changes in Pancreas were documented after screening acute toxicity of both extracts. Results: Chromatographic separation and identification of GS-AE revealed the presence of Saponins and glycosides, which have also been confirmed in PH-AE by Phytochemical tests. Though GS-AE showed good control over blood sugar, after 21 days GS-AE and Glibenclamide treated groups still had 56.25% and 41.60% sugar levels, respectively, in hyperglycemic rats whereas Polyherbal extracts exhibited highly significant (P ≤ 0.001) antidiabetic activity when compared to Glibenclamide by leaving only 6% increased residual sugar level in comparison to control. The activity was also substantiated by normalization of histopathological architecture of pancreas. Conclusion: Our results indicate that Polyherbal extract shows synergism among its components, which could emerge as a novel potent antidiabetic formulation to combat diabetes through clinical trials.

Publisher

Faculty of Pharmaceutical Sciences, Chulalongkorn University

First Page

449

Last Page

453

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