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The Thai Journal of Pharmaceutical Sciences

Abstract

Objectives: Dexamethasone (Dex) is an anti-inflammatory drug with serious side effects. The aim of this study was to investigate, antioxidants status, antihyperlipidemic activity, and serum electrolyte levels of rats treated with Vitamin E in Dex-induced oxidative stress. Materials and Methods: Wistar rats of both sexes were assigned to four groups (n = 6). The control group was fed with standard rat feed and water, while Dex group received 30 μg/kg of Dex. Vitamin E group received 300 IU/kg of vitamin E, while Dex + Vitamin E group received 30 μg/kg of Dex and 300 IU/kg of vitamin E. After 14 days of administration, blood samples were taken through cardiac puncture for biochemical analysis and the liver for histological analysis. Results: Triglyceride, low-density lipoprotein-cholesterol, and malondialdehyde levels were significantly (P < 0.05) raised, while high-density lipoprotein (HDL)-cholesterol and superoxide dismutase (SOD) were reduced in Dex only group when compared with control and vitamin E only groups. The treatment with vitamin E significantly (P < 0.05) reduced these biochemical parameters and increased HDL-cholesterol and SOD level when compared with Dex group. Electrolyte levels in Dex only and vitamin E-treated groups were comparable with the control group. Conclusion: Vitamin E can ameliorate hyperlipidemia and antioxidant imbalance caused by Dex in rats.

Publisher

Faculty of Pharmaceutical Sciences, Chulalongkorn University

First Page

441

Last Page

448

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